RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--Precision BioSciences, Inc., a leader in the field of genome engineering, today announced that the United States Patent and Trademark Office (PTO) has issued Notices of Allowance for U.S. Patent Applications 13/246,270 and 13/246,346 (“the '270 and ‘346 Applications”). The allowed claims relate to an assortment of genome engineering methods, including the use of defined engineered meganucleases in isolated human cells. These methods constitute an important aspect of Precision’s genome engineering technology known as the Directed Nuclease Editor or DNE.