Possible “Class Effect” For Proton-Pump Inhibitors On Top Of Clopidogrel Therapy

The Heart -- One-year risk of cardiovascular events is increased more than 50% in patients taking a proton-pump inhibitor (PPI) on top of clopidogrel, as compared with patients not taking a PPI, and the risk seems to be a class effect, according to a retrospective cohort study of more than 16 700 patients who received clopidogrel poststenting.