NJ Biz -- Pharmaceutical mega-mergers — like those between Pfizer and Wyeth, and between Merck and Schering-Plough — have perhaps reached a tipping point where it may get harder to justify them, according to panelists at PharmFest 2010, a daylong conference held Monday at Montclair State University, in the Essex County township. The HealthCare Institute of New Jersey co-sponsored the event with the university.