In a paper to be published in the Nov. 25 issue of Proceedings of the National Academy of Sciences, the laboratory of cancer geneticist Alfonso Bellacosa, M.D., of Fox Chase Cancer Center reports new findings linking a novel genetic mutation to the ability of human cancers to resist certain anticancer drugs. The paper, entitled “The Base Excision Repair Enzyme MED1 Mediates DNA Damage Response to Anti-Tumor Drugs and Is Associated with Mismatch Repair System Integrity,” will first appear in the PNAS Online Early Edition (http://www.pnas.org) the week of Nov. 10-14.
