H. Lee Moffitt Cancer Center & Research Institute, working in partnership with the University of South Florida (USF), has discovered a new use for an old, previously discredited anti-cancer drug that could add another weapon in the arsenal against several cancers, including tumors of the breast, ovary, colon, skin and prostate. The compound, tricirbine, was tested at various cancer centers from 1982 to 1996 and found to inhibit some cancers, but researchers failed to determine why. The Moffitt-USF team discovered that tricirbine works only against tumors in which the cancer-causing Akt protein is abundant and/or abnormally active. “These tumors are addicted to hyperactive Akt and cannot survive without it,” explains Saïd Sebti, Ph.D., Moffitt’s Manuel and Adeline Garcia Professor, Leader of the Drug Discovery Program and Associate Director of Moffitt Research Institute. “What we discovered is a tailored therapy for tumors with a specific molecular signature.” Resurrecting tricirbine may be promising for patients with ovarian cancer, for instance, because “40 percent of women with ovarian cancer have tumors with high levels of active Akt,” according to Sebti. “To our knowledge, this is the first Akt inhibitor headed toward clinical trials,” said Jin Cheng, MD, PhD, USF Professor of Pathology and Interdisciplinary Oncology. Cheng and Sebti’s study results were published in the journal Cancer Research.
