ROCHESTER, Minn.--(BUSINESS WIRE)--A new Mayo Clinic (http://www.mayoclinic.org/) study has found that the type of tissue damage changes throughout the course of multiple sclerosis (http://www.mayoclinic.org/multiple-sclerosis/) (MS). In early relapsing disease stages, the plaques, or areas where the nervous system is inflamed or demyelinated, are predominantly active with distinct heterogeneous patterns of myelin damage. Later in the chronic progressive phase of the disease, smoldering and inactive plaques predominate, and are characterized by a uniform pattern of tissue damage.