Medwire -- MedWire News: Results from the LOWERING-IT trial support the use of a moderate oral anticoagulation regimen in low risk patients following mechanical aortic valve replacement (AVR). The study compared the outcome of warfarin-treated patients set a low International Normalized Ratio (INR) target of 1.5-2.5 with those using the conventional INR target of 2.0-3.0.
