A growing body of evidence suggests that in utero and early-life exposure to arsenic may have detrimental effects on children, even at the low to moderate levels common in the United States and elsewhere. The fetus starts to develop toenails during the first trimester, making them an accurate measure of exposure to arsenic during the entire gestation. Prior studies that used infant toenails as a biomarker of in utero exposure were conducted in highly exposed populations.
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