Impaired Fetal Environment Linked to Lower Survival After Heart Surgery in Newborns

--CHOP Researchers: Impact May Last Years after Initial Surgery--

PHILADELPHIA, May 30, 2018 /PRNewswire-USNewswire/ -- Children who undergo surgery for congenital heart disease have lower survival rates by three years of age if there are specific problems during fetal development, such as hypertension in the mother or the newborn being born preterm or small for gestational age. These problems are considered markers of an impaired maternal-fetal environment (MFE).

“We already knew that an impaired maternal-fetal environment correlates with neonatal mortality and morbidity in children who don’t have heart disease,” said study leader J. William Gaynor, MD, a pediatric cardiologist at Children’s Hospital of Philadelphia (CHOP). “In this study, we investigated the impact of those impairments on child outcomes after infant heart surgery.”

Gaynor and colleagues published their study online Feb. 13 in the European Journal of Cardio-Thoracic Surgery.

The researchers performed a retrospective analysis of 135 newborns with congenital heart disease (CHD) from a larger study of neurodevelopment outcomes after infant cardiac surgery. Two thirds of the cohort of 135 infants had transposition of the great arteries or hypoplastic left heart syndrome (HLHS). The study team defined an impaired MFE as involving pre-eclampsia in the mother, being small for gestational age, or being born preterm. Pre-eclampsia entails gestational hypertension, plus either protein in the urine or injury to the liver or kidney.

In the study cohort, 28 of the 135 newborns, or 21 percent, experienced an impaired MFE. Those infants had longer hospital stays after surgery than the infants without an impaired MFE. Hospital mortality was similar for both groups, but survival at 36 months of age was significantly lower for children with an impaired MFE (68 percent vs. 96 percent). Within the subgroup of patients with HLHS, survival was also lower among those with an impaired MFE.

“Evidence is mounting that the MFE and the placenta are abnormal in many fetuses with CHD, with adverse effects on early development,” said Gaynor. Impaired neonatal growth, in turn, may predict worse surgical outcomes. In addition, he added, there is increasing recognition that CHD in a fetus is associated with the mother’s health as well.

The researchers noted that the impact of an impaired MFE may extend for years after the initial surgery--here, up to age three. Further studies, said Gaynor, should investigate the mechanisms driving MFE in fetuses with CHD, and on potential strategies to improve the MFE.

CHOP is particularly well positioned to pursue research into the maternal-fetal environment, because the hospital houses the Center for Fetal Diagnosis and Treatment (CFDT), one of the world’s largest and most comprehensive fetal therapy centers, and the Fetal Heart Program, a dedicated team of physicians, nurses and imaging specialists focused on fetal cardiovascular conditions. The CFDT also includes the Garbose Family Special Delivery Unit, the first obstetrical delivery unit in a pediatric hospital dedicated to the care and delivery of high-risk fetuses with complex anomalies requiring medical or surgical interventions and care immediately after birth.

Mark P. Johnson, MD, a co-author of the current study and Director of Obstetrical Services in the CFDT, said, “An impaired MFE may result in functional immaturity and abnormal development of multiple organ systems, including the heart. Whether this abnormal development raises the risk of higher infant mortality after heart surgery is a question that merits further investigation.”

James William Gaynor et al, “The impact of the maternal-foetal environment on outcomes of surgery for congenital heart disease in neonates,” European Journal of Cardio-Thoracic Surgery, online Feb. 13, 2018. http://doi.org/10.1093/ejcts/ezy015

Children’s Hospital of Philadelphia: Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, Children’s Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. In addition, its unique family-centered care and public service programs have brought the 546-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu

Natalie Solimeo
Children’s Hospital of Philadelphia
(267) 426-6246
Virgilion@email.chop.edu