SAN DIEGO--(BUSINESS WIRE)--Halozyme Therapeutics, Inc. (Nasdaq:HALO) and Roche today announced dosing of the first patient in a Phase 3 registration trial using Enhanze™ technology (rHuPH20, recombinant human hyaluronidase) in a subcutaneous formulation with Roche’s anticancer biologic, Herceptin (trastuzumab). This represents the first Roche product to enter a Phase 3 registration study as part of the Halozyme Roche collaboration and initiation of the clinical trial has triggered a milestone payment of $5 million to Halozyme. Herceptin is approved to treat HER2-positive breast cancer and currently is given intravenously (IV).