WebMD -- A ghostly “suicide” drug wafts into immune cells in joints, making the cells self-destruct and reducing rheumatoid arthritis in mice. The drug, technically a BH3 mimetic dubbed TAT-BH3, is a man-made molecule. One part of the molecule lets it drift through cell walls. The other part mimics a chemical signal missing in the macrophage immune cells that build up inside joints afflicted by rheumatoid arthritis (RA).
