WASHINGTON (Reuters) - Variants of the BMP2 gene -- for bone morphogenetic protein 2 -- may put some women at a higher risk for osteoporosis, researchers in Iceland reported on Monday.
Researchers at deCODE Genetics Inc. in Iceland identified the gene by screening a nationwide genealogical database of Icelanders. The database takes advantage of the small, inbred population that dates back to immigrants who settled the island 1,100 years ago.
Already known to be involved in bone development, the gene has several versions. The researchers found that about 30 percent of those tested had one of three versions of the gene that gave them three times the risk of osteoporosis compared to others.
The team double-checked using data from Danish women and confirmed their findings, they report in this week’s issue of the Public Library of Science.
“There are over a million osteoporotic fractures per year in the United States, with a total direct medical cost exceeding $10 billion dollars annually,” deCODE said in a statement.
“By identifying those at elevated risk before they begin to lose bone mass, it may be possible to more closely monitor bone density and implement more targeted and effective prevention strategies, involving lifestyle changes and-or existing medications,” it added.
“A better understanding of the genetics of osteoporosis may also contribute to a better understanding of the biology of the disease, and thus to the development of new and more effective drugs.”
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