Foundational Publication Validates Acutus AcQMap System’s Breakthrough Non-Contact Technology

CARLSBAD, Calif., March 25, 2019 /PRNewswire/ -- Acutus Medical today announced the publication of “High Resolution Non-Contact Charge Density Mapping of Endocardial Activation” in JCI Insight. This foundational manuscript indicates that charge mapping enables unmatched visualization of the conduction patterns and localized non-pulmonary vein (PV) therapeutic targets in patients with atrial arrhythmias, such as atrial fibrillation (AF).

Investigators examined clinical cases using the charge density AcQMap platform to verify that AF is a mappable arrhythmia with repetitive patterns. This breakthrough conclusion has been historically elusive due to the limitations of traditional voltage mapping, which is hindered by far-field interference.

“These findings comprehensively address a misguided presumption amongst physicians that AF is a chaotic, mysterious arrhythmia,” said principal author Dr. Andrew Grace, Royal Papworth Hospital, Cambridge, England. “My peers and the generations of electrophysiologists that came before us could not have imagined the level of detail we can now visualize—in real time. Through the previously unmatched capabilities of charge density mapping, we can confirm that atrial fibrillation is a mappable arrhythmia that is furthermore open to pragmatic, clinically relevant classification. Armed with this knowledge, therapeutic strategies will evolve to more effectively treat each individual arrhythmia patient. It is a phenomenal technology with far reaching applications, both therapeutic and scientific.”

The manuscript includes data from the DDRAMATIC-SVT trial (NCT01875614), in which clinicians identified cardiac regions of interest using AcQMap, developed an ablation strategy and confirmed effectiveness by remapping using the unique non-contact charge density mapping and ultrasound imaging system.

“AcQMap mapping technology was developed from first principles of electrostatic field theory to overcome the limitations of noisy voltage measurements,” said Acutus Medical CEO Vince Burgess. “With the Acutus cardiac visualization system, we can observe and analyze atrial arrhythmias such as AF for the first time. Together with our international group of scientific and clinical collaborators, we have created a system that allows electrophysiologists to tailor treatments for each individual patient and then adapt that treatment iteratively—on the fly—while the patient is still in the EP lab. This publication confirms our long-standing high expectations for this technology and is a critical milestone for patients, physicians and researchers, marking a new era of unparalleled resolution of cardiac activation that will vastly improve the understanding and treatment of arrhythmias.”

About Acutus Medical
Acutus Medical is a dynamic arrhythmia care company focused on developing distinct, innovative technologies that provide physicians and patients with improved results. At Acutus, we know that seeing is better than believing. Diagnosing and treating patients with atrial arrhythmias requires eliminating the unknown. Acutus’ advanced cardiac imaging and mapping system provides real-time arrhythmia visualization displaying the heart’s true activation pattern, turning the chaos of an atrial arrhythmia into a clear vision for electrophysiologists. Founded in 2011, Acutus is based in Carlsbad, California.

Indications for Use
In the U.S., the AcQMap System is intended for use in patients for whom electrophysiology procedures have been prescribed. When used with the AcQMap Catheters, the AcQMap System is intended to be used to reconstruct the selected chamber from ultrasound data for purposes of visualizing the chamber anatomy and displaying electrical impulses as either dipole density-based or voltage-based maps of complex arrhythmias that may be difficult to identify using conventional mapping systems alone. And, when used with the specified Patient Electrodes, the AcQMap System is intended to display the position of AcQMap Catheters and conventional electrophysiology (EP) catheters in the heart.

In the EU, the AcQMap System is intended for use in patients for whom electrophysiology procedures have been prescribed. When used with the AcQMap Catheters, the AcQMap System is intended to be used in the right and/or left atria to visualize the selected chamber and display atrial electrical impulses. And, when used with patient electrodes, the AcQMap System is intended to display the position of AcQMap Catheters and conventional electrophysiology (EP) catheters in the heart.

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SOURCE Acutus Medical