Entasis Therapeutics Presents Data on Sulbactam-Durlobactam and ETX0462 at 2022 ASM Microbe Annual Conference

WALTHAM, Mass., June 09, 2022 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc. (Nasdaq: ETTX), a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced multiple presentations at the American Society for Microbiology (ASM) annual Microbe conference, taking place June 9-13, 2022, in Washington, DC. Entasis is presenting data on sulbactam-durlobactam (SUL-DUR), an investigational drug in development for the treatment of infections caused by Acinetobacter baumannii including carbapenem-resistant and multidrug-resistant (MDR) strains, and ETX0462 a novel, first-in-class, diazabicyclooctane with broad spectrum antimicrobial activity against MDR Gram-negative bacteria, including Pseudomonas aeruginosa.

Details of the presentations are as follows:

Sulbactam-Durlobactam

Oral Presentations:

Sulbactam-durlobactam (SUL-DUR), a targeted β-lactam/β-lactamase inhibitor, for MDR Acinetobacter infections
Presenter: Alita A. Miller; June 10 8:15am; Salon GHI

Pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex (ABC)
Presenter: John O’Donnell; June 11 3:00pm; Salon C

Poster Presentations (Poster Hall):

#3114:In vitro activity of sulbactam-durlobactam against recent clinical Acinetobacter baumannii-calcoaceticus complex isolates from the United States
June 10
Presenter: Alita A. Miller

#3473: In vitro activity of sulbactam-durlobactam against Acinetobacter baumannii clinical isolates collected in 2020 from China
June 10
Presenter: Sarah M. McLeod

#3490: Potent activity of sulbactam-durlobactam against pan-drug resistant Acinetobacter baumannii-calcoaceticus complex (ABC) isolates from a recent 5-year surveillance study (2016-2020)
June 10
Presenter: Sarah M. McLeod

#2776:In vitro activity of sulbactam-durlobactam in combination with other antimicrobial agents
June 11
Presenter: Alita A. Miller

#2797: Sulbactam-durlobactam is bactericidal against clinical isolates of Acinetobacter baumannii
June 11
Presenter: Sarah M. McLeod

ETX0462

Oral Presentations:

ETX0462, a novel non-β-lactam PBP inhibitor, has potent antibacterial activity against a panel of geographically diverse Gram-negative bacterial clinical isolates
Presenter: Alita A. Miller, June 10 2:45pm; Salon GHI

Poster Presentation (Poster Hall):

#3214: ETX0462, a novel non-β-lactam PBP inhibitor, does not induce AmpC expression
June 10
Presenter: Alita A. Miller

About Entasis Therapeutics Holdings Inc.
Entasis is a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Entasis’ pathogen-targeted design platform has produced a pipeline of product candidates, including SUL-DUR (targeting Acinetobacter baumannii infections), zoliflodacin (targeting Neisseria gonorrhoeae infections), ETX0282CPDP (targeting Enterobacterales infections) and ETX0462 (targeting Gram-negative infections including Pseudomonas). For more information, visit www.entasistx.com.

Entasis Forward-looking Statements
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