A Mayo Clinic discovery about a protein known as Dynamin-2 has thrown conventional wisdom for a loop. Finding the protein on the centrosome, a minute structure near a cell’s nucleus, may lead to new strategies for stopping cancer growth. The Mayo team, already known for discovering several families of dynamins, this time discovered them -- not on a membrane, as expected -- but on the unlikely centrosome which has no membrane. It was the last place they expected to find them, but the surprise finding offers a new lead in the fight against cancer.