SOUTH SAN FRANCISCO, CA--(Marketwire - April 17, 2008) - Cytokinetics, Incorporated (NASDAQ: CYTK) announced today the selection of a development compound that is directed towards a molecular target in the skeletal sarcomere. This compound is a highly specific small molecule activator of the troponin complex, increasing its sensitivity to calcium, and subsequently leading to an increase in skeletal muscle contractility. This mechanism of action has demonstrated encouraging pharmacological activity in non-clinical models that may relate to potential treatment of diseases associated with aging and neuromuscular wasting. The potential drug candidate is the fifth development compound to emerge from the company’s research activities which have focused on discovering novel therapeutics directed towards cytoskeletal biology.
