Experiments in female monkeys have for the first time shown that when used in combination, vaginal gels known as microbicides can protect against an HIV-like virus. The research, funded largely by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), suggests that similar combination microbicides could potentially provide a safe, effective and practical way to prevent HIV transmission to women, according to study investigators. The study, published online October 30 in the journal Nature, represents the first successful testing of combination microbicides in a primate model.