BioChain is expanding its current product line of NGS-characterized bio-samples by offering ready-to-use BRCA-characterized FFPE/frozen sections/blocks for preclinical drug development and as reference samples for CLIA labs.
BioChain is expanding its current product line of NGS-characterized bio-samples by offering ready-to-use BRCA-characterized FFPE/frozen sections/blocks for preclinical drug development and as reference samples for CLIA labs.
These BRCA-characterized samples are excellent reference tissues for scientists in the oncology field who are studying pathways related to BRCA1 and BRCA2.
BRCA1 and BRCA2 are tumor suppressor genes found in humans which encode proteins that function in DNA repair. Mutations within BRCA genes result in the loss of this important function and are therefore linked to susceptibility of certain cancers, such as: breast, ovarian, pancreatic, prostate, and skin cancers. BioChain has collected many tumor samples in both frozen and FFPE format with the aim of characterizing the DNA for BRCA mutations. We first isolated genomic DNA from the frozen tumor tissues and then processed them for subsequent NGS characterization using Paragon genomics’s BRCA1&2 panel.
Currently these samples all derive from breast cancer donors as the BRCA genes are strongly linked to oncogenesis in this tissue type. However, we will continue to characterize additional tissue types where cancer development is linked to BRCA mutations.
In several cases, samples may be available as matched sets which include the adjacent normal/primary tumor tissue along with plasma from the same donor. Our other ready to use NGS characterized tissue inventory includes MSI-High, MSI-Stable, HPV positive/negative, EGFR, KRas donors.
BioChain is the world leader in high quality processed bio-sample products and analysis services used in advancing translational medicine, companion diagnostics, and clinical product research and development. BioChain’s products are available for DNA and RNA sequencing, PCR and RT-PCR, gene expression analysis, DNA and RNA purification, protein extraction and purification, and protein expression analysis. BioChain’s One-Stop Services for Next Generation Sequencing, from clinical sample collection, sample preparation, sequencing to bioinformatics analysis, will revolutionize the industry.
BioChain Institute, Inc.
For Information:
P: 888-762-2568
E: info@biochain.com