LONDON & CAMBRIDGE, England--(BUSINESS WIRE)--Origin Sciences Ltd, a medical technology company developing innovative diagnostics and devices for investigating GI diseases, has published new data showing the effectiveness of its OriCol™ sampling device in gut microbiome research and development.
The trial compared the microbiome profile of OriCol™ and stool samples taken at three different time points from healthy subjects. A single rectal swab sample was also obtained from each subject. The microbiome data, which was produced and analysed by Second Genome, Inc., showed that the range and trends in alpha diversity between subjects were mirrored in OriCol™ and stool samples, however the rectal swab samples showed lower diversity. Whole microbiome abundance profiles were significantly different between OriCol™ and stool samples when grouped by subject or sample type. Whilst specific families of bacteria belonging to the phyla Bacteriodetes, Firmicutes and Proteobacteria were enriched in OriCol™ samples, other families of bacteria belonging to the phyla Actinobacteria as well as different families within the Bacteriodetes phyla were enriched in stool. Subject to subject comparisons demonstrated that the OriCol™ device is able to capture donor-to-donor differences found in stool samples, but the microbial community differs in the two sample types.
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The trial compared the microbiome profile of OriCol™ and stool samples taken at three different time points from healthy subjects. A single rectal swab sample was also obtained from each subject. The microbiome data, which was produced and analysed by Second Genome, Inc., showed that the range and trends in alpha diversity between subjects were mirrored in OriCol™ and stool samples, however the rectal swab samples showed lower diversity. Whole microbiome abundance profiles were significantly different between OriCol™ and stool samples when grouped by subject or sample type. Whilst specific families of bacteria belonging to the phyla Bacteriodetes, Firmicutes and Proteobacteria were enriched in OriCol™ samples, other families of bacteria belonging to the phyla Actinobacteria as well as different families within the Bacteriodetes phyla were enriched in stool. Subject to subject comparisons demonstrated that the OriCol™ device is able to capture donor-to-donor differences found in stool samples, but the microbial community differs in the two sample types.
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