SYDNEY, Australia & SAN DIEGO & HONOLULU--(BUSINESS WIRE)--March 16, 2006--Avantogen Limited (Avantogen) (ASX:ACU), and Hawaii Biotech, Inc. (Hawaii Biotech), a privately held company, today announced that they have entered into a Definitive Agreement to combine their respective vaccine businesses. The combined business, as yet unnamed, will be 50% owned each by Hawaii Biotech’s current shareholders and Avantogen Limited and will focus exclusively on prophylactic and therapeutic vaccine development.