Zealand Pharma and DEKA Research & Development Corp. Announce Collaboration Agreement to Advance Development of Infusion Pump to Be Used with Dasiglucagon for Treatment of Congenital Hyperinsulinism (CHI)
Company announcement – No. 66/ 2021
Zealand Pharma and DEKA Research & Development Corp. Announce Collaboration Agreement to Advance Development ofInfusion Pump to Be Used with Dasiglucagonfor Treatment of Congenital Hyperinsulinism (CHI)
- Agreement grants Zealand a worldwide, exclusivelicense to use DEKA’s continuous infusion pumpfor the potentialtreatment of CHI with dasiglucagon
- DEKA will be responsible for pump development and manufacturing
- Zealand will be responsible for clinical development of the drug-device combination and commercialization in all territories
Copenhagen, DK and Boston, MA, U.S. November05, 2021 – Zealand Pharma A/S (Nasdaq: ZEAL) (CVR-no. 20045078,) a biotechnology company focused on the discovery, development and commercialization of innovative peptide-based medicines, today announced that it has entered into definitive collaboration agreements with DEKA Research & Development Corp., to develop a continuous infusion pump to be used in combination with dasiglucagon, an investigational agent currently in phase 3 trials in patients with congenital hyperinsulinism. The agreement covers the technical development of the pump system as well as associated manufacturing and commercialization activities.
“As we progress toward completion of our pivotal clinical trials for dasiglucagon as a potential treatment option for CHI, we are thrilled to announce this collaboration agreement with DEKA,” said Emmanuel Dulac, President and Chief Executive Officer of Zealand Pharma. “DEKA’s innovative drug infusion pump has been FDA cleared in other uses and it represents an attractive potential solution for dasiglucagon administration in CHI, taking us one step closer to achieving our goal of improving the lives of CHI patients and their families.”
“We are very pleased to be working with Zealand, leveraging our long experience with infusion pumps to aid in their development of a new treatment option for CHI,” said Dean Kamen, Founder of DEKA. “Our mission at DEKA is to develop technology that can solve problems and improve people’s lives - this collaboration is a great example of how we work to fulfill that mission.”
Under the terms of the agreement, DEKA and Zealand will develop a medical pump system that is suitable for use in combination with dasiglucagon. DEKA and its affiliates will be responsible for pump development and pump manufacturing activities. Zealand will be solely responsible for clinical development around the drug-device combination as well as for distribution and commercialization in all territories.
CHI is a rare pediatric disease that affects mainly newborns, infants and toddlers. Due to a genetic defect in the insulin producing cells, these children have increased insulin levels, resulting in persistent and recurrent hypoglycemia throughout childhood. Current treatment options are limited, complex and may be insufficient to adequately control hypoglycemia.
Invented by Zealand Pharma, dasiglucagon is a glucagon analog that is stable in aqueous solution and is thus suitable for chronic pump use. In 2017, both the U.S. Food and Drug Administration (FDA) and the European Commission granted orphan drug designation for dasiglucagon for the treatment of CHI.
About DEKA Research & Development Corp.
Based in Manchester, NH, DEKA is a research and development company comprised of engineering, manufacturing and quality assurance professionals focused on the development of new technologies that span a diverse set of applications. The company was founded in 1982 by Dean Kamen, an inventor who holds hundreds of U.S. and foreign patents and numerous awards, many of them for innovative medical devices that have expanded the frontiers of healthcare worldwide.
About Zealand Pharma A/S
Zealand Pharma A/S (Nasdaq: ZEAL) ("Zealand") is a biotechnology company focused on the discovery, development, and commercialization of peptide-based medicines. More than 10 drug candidates invented by Zealand have advanced into clinical development, of which two have reached the market and three candidates are in late-stage development. Zealand markets V-Go® and Zegalogue® (dasiglucagon) injection. In addition, license collaborations with Boehringer Ingelheim and AstraZeneca create opportunities for more patients to potentially benefit from Zealand-invented peptide investigational agents currently in development.
Zealand was founded in 1998 in Copenhagen, Denmark, and has presence throughout the U.S. that includes key locations in Boston, and Marlborough (MA). For more information about Zealand’s business and activities, please visit http://www.zealandpharma.com.
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