TwinStrand Biosciences Announces Peer-Reviewed Publication of Study Results Highlighting Ability of Duplex Sequencing Technology to Rapidly Detect the Mutagenic Activity of Chemicals
SEATTLE, Dec. 15, 2020 /PRNewswire/ -- TwinStrand Biosciences, Inc., a next-generation DNA sequencing technology company, announced today the publication of a study validating a new application of its TwinStrand Duplex Sequencing™ Technology. Study findings demonstrated the ability of Duplex Sequencing to rapidly detect and characterize ultra-low frequency mutations and early cancer growth caused by chemical carcinogens in mouse models. The study, "Direct Quantification of in vivo Mutagenesis and Carcinogenesis Using Duplex Sequencing," was peer-reviewed and published in the Proceedings of the National Academy of Sciences (PNAS).
Duplex Sequencing is a biochemistry and cloud-based software enhancement to existing next-generation sequencing (NGS) platforms that improves accuracy by more than 10,000-fold. This dramatic performance boost enables researchers and clinicians to solve previously intractable genetic "needle in a haystack" problems by revealing the faint signals of exceptionally rare DNA mutations that until now have been obscured by technical noise.
"There are significant limitations associated with current tools for mutagenesis detection, largely related to the need to use bacteria or genetically-modified organisms that produce only limited and indirect measurement of induced mutations. The unprecedented richness of data unlocked through Duplex Sequencing will contribute to the revitalization of genetic toxicology and mutational science and will help expedite numerous fields of research and development," said Jesse Salk, M.D., Ph.D., CEO of TwinStrand Biosciences. "These findings have the potential to expand real-world applications for Duplex Sequencing, including fast in vivo and in vitro preclinical testing to accelerate drug development, high resolution off-target mutagenesis evaluation of CRISPR and other gene editing technologies and in-human use to non-invasively identify exposures to environmental carcinogens to aid public health officials with surveillance and source control."
The study, which was conducted in partnership with researchers at Millipore Sigma/BioReliance® Toxicology Services and Amgen®, demonstrated the ability of Duplex Sequencing to accurately measure chemical mutagenesis and early carcinogenesis in comparison with standard in vivo mutagenesis assays.
Key findings highlighted in the scientific paper include:
TwinStrand Biosciences launched Duplex Sequencing mutagenesis kits in February 2020. In addition to a mouse mutagenesis assay, the company offers human and rat mutagenesis assays as well as an assay for the detection of minimal residual disease in acute myeloid leukemia, among others in development.
The scientific paper can be accessed on TwinStrand Biosciences' website at www.twinstrandbio.com/resources/publications.
About TwinStrand Biosciences
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SOURCE TwinStrand Biosciences, Inc.