Iovance Biotherapeutics Presents Clinical Data in Head and Neck Cancer at Society for Immunotherapy of Cancer (SITC) 35th Annual Meeting
SAN CARLOS, Calif., Nov. 09, 2020 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies (tumor-infiltrating lymphocyte, TIL and peripheral-blood lymphocyte, PBL), today presented new interim clinical data for the tumor infiltrating lymphocyte (TIL) therapy LN-145 in combination with pembrolizumab in advanced, recurrent, or metastatic head and neck squamous cell carcinoma (HNSCC) who are immune checkpoint inhibitor (ICI) naive at the 35th Anniversary Annual Meeting of the Society for Immunotherapy of Cancer (SITC).
“We are very pleased to present initial safety and efficacy data for our tumor infiltrating lymphocyte (TIL) cell therapy LN-145 in combination with pembrolizumab as a potential new therapeutic approach in ICI naive head and neck cancer,” said Maria Fardis, Ph.D., President and Chief Executive Officer of Iovance Biotherapeutics. “Following one-time TIL administration and pembrolizumab as per the approved label, the overall response rate was 44.4 percent and median duration of response has not been reached at 8.6 months of study follow up in patients with advanced, recurrent, or metastatic HNSCC. This is the first time that combination of Iovance TIL with anti-PD-1 antibody data is being presented in ICI naive patients. We continue evaluating the combination of TIL with pembrolizumab in additional solid tumor indications and look forward to presenting our findings as our program progresses.”
New interim results from the ongoing IOV-COM-202 study of LN-145 in various settings and indications are now available from Cohort 2A in a poster titled, “Safety and efficacy of tumor infiltrating lymphocytes (TIL; LN-145) in combination with pembrolizumab for advanced, recurrent or metastatic HNSCC.” As of the October 16, 2020 data extract date for the poster, LN-145 in combination with pembrolizumab shows a 44.4% overall response rate (ORR) (one complete response and three partial responses) and a disease control rate of 88.9% (n=9). Median DOR was not reached at 8.6 months of median study follow up (1.0+ to 10.9+ months).
The HNSCC patients in Cohort 2A were PD-1 blockade naive and 89 percent had progressed on prior chemotherapy (1.0 mean prior line of therapy). The adverse event profile of the combination therapy was consistent with those of pembrolizumab and TIL therapy, lymphodepletion and IL-2, as well as the underlying disease. HPV status was positive in four patients, negative in three patients and unknown in two patients. CPS scores were greater than or equal to 20 in five patients, below 20 in two patients and missing in two patients. The poster is available in the “Publications and Scientific Presentations” section of the Iovance corporate website.
Posterin Head and Neck Cancer at SITC Annual Meeting(November 9-14, 2020):
- Abstract #353: Safety and efficacy of tumor infiltrating lymphocytes (TIL; LN-145) in combination with pembrolizumab for advanced, recurrent or metastatic HNSCC
- Authors: A Jimeno, et al.
- Presentation Times: Wednesday, Nov. 11, from 5:15-5:45 p.m. EST and Friday, Nov. 13, from 4:40-5:10 p.m. EST.
- Location: Virtual Poster Hall at www.sitcancer.org
About Iovance Biotherapeutics, Inc.
Iovance Biotherapeutics aims to improve patient care by making T cell-based immunotherapies broadly accessible for the treatment of patients with solid tumors and blood cancers. Tumor infiltrating lymphocyte (TIL) therapy uses a patient’s own immune cells to attack cancer. TIL cells are extracted from a patient’s own tumor tissue, expanded through a proprietary process, and infused back into the patient. After infusion, TIL reach tumor tissue, where they attack tumor cells. The Company has completed dosing in the pivotal study in patients with metastatic melanoma and is currently conducting a pivotal study in patients with metastatic cervical cancer. In addition, the
Company’s TIL therapy is being investigated for the treatment of patients with locally advanced, recurrent or metastatic cancers including head and neck and non-small cell lung cancer. A clinical study to investigate Iovance T cell therapy for blood cancers called peripheral blood lymphocyte (PBL) therapy is open to enrollment. For more information, please visit www.iovance.com.
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Iovance Biotherapeutics, Inc:
Sara Pellegrino, IRC
Vice President, Investor Relations & Public Relations
650-260-7120 ext. 264
Chad Rubin (investors)
Rich Allan (media)