Agilent Announces Update on PD-L1 CE-IVD in Urothelial Carcinoma
PD-L1 IHC 22C3 pharmDx Can Now Be Used as an Aid to Identify Urothelial Carcinoma Patients for Treatment With KEYTRUDA® (pembrolizumab)
Physicians in Europe can now use the assay as an aid to identify urothelial carcinoma patients who are ineligible for cisplatin and may respond to KEYTRUDA (pembrolizumab) as a first-line treatment option. KEYTRUDA is a targeted anti-PD-1 immunotherapy manufactured by Merck (known as MSD outside the United States and Canada). It is a humanized monoclonal antibody that may increase the ability of the body's immune system to help detect and fight tumor cells.
“We are pleased that PD-L1 IHC 22C3 pharmDx will help physicians identify urothelial carcinoma patients for whom KEYTRUDA may be an appropriate first-line treatment option. Being able to support the use of immuno-oncology therapeutics by bringing their associated diagnostics to market is truly encouraging,” said Sam Raha, president of Agilent's Diagnostics and Genomics Group.
Agilent is a worldwide leader in partnering with pharmaceutical companies to develop immunohistochemical-based diagnostics for cancer therapy. Agilent developed PD-L1 IHC 22C3 pharmDx in partnership with Merck. PD-L1 expression in urothelial carcinoma tissues is interpreted using Combined Positive Score (CPS). PD-L1 IHC 22C3 pharmDx also helps physicians identify non-small cell lung cancer (NSCLC) patients for treatment with KEYTRUDA. PD-L1 expression in NSCLC tissues is interpreted using Tumor Proportion Score (TPS).
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Source: Agilent Technologies Inc.