AMEX To Trade Options On Advanced Magnetics, Inc.

The American Stock Exchange(R) (Amex(R)) will launch trading in options on Friday, March 31, 2006 on the following American Stock Exchange listed stock of:

* Advanced Magnetics, Inc.

Advanced Magnetics, Inc. options will open with strike prices of 30 - 35 - 40 and position limits of 2,500,000 shares. The options will trade on the February expiration cycle with initial expirations in March, April, July and October. The Specialist will be Jane Street Specialists, LLC. Advanced Magnetics, Inc. develops, manufactures and markets organ-specific contrast agents to improve the diagnostic capabilities of soft tissue magnetic resonance imaging (MRI) scans.

For more information on any Amex-listed company, please visit http://www.amex.com.

The American Stock Exchange(R) (Amex(R)) is the only primary exchange that offers trading across a full range of equities, options and exchange traded funds (ETFs), including structured products and HOLDRS(SM). In addition to its role as a national equities market, the Amex is the pioneer of the ETF, responsible for bringing the first domestic product to market in 1993. Leading the industry in ETF listings, the Amex lists 162 ETFs. The Amex is also one of the largest options exchanges in the U.S., trading options on broad-based and sector indexes as well as domestic and foreign stocks. For more information, please visit http://www.amex.com.

American Stock Exchange