Beckman Coulter introduces the Agencourt RNAdvance Tissue system for isolation of total RNA from mammalian samples. The Agencourt RNAdvance Tissue process is based on the patented Agencourt SPRI® (Solid Phase Reversible Immobilization) paramagnetic bead nucleic acid purification technology. The new system produces clean RNA with high recovery, in single-tube or 96-well formats, while eliminating organic solvents, vacuum filtration and centrifugation steps. The simple Agencourt RNAdvance Tissue procedure enables higher recovery of total RNA than traditional column-based approaches. This allows researchers to maximize the use of precious tissue samples without compromising RNA integrity.