WALTHAM, Mass.--(BUSINESS WIRE)--X-Chem, Inc., a privately held biotechnology company focused on applying its powerful product engine to the generation of novel small molecule therapeutics, today announced that the company has created the first biotech-owned screening library of DNA-encoded small molecules to ever surpass 100 billion compounds. Its size now far exceeds that of even the largest conventional small molecule screening libraries by 10,000-fold, and its diversity is unprecedented. The library was created using the company’s cutting-edge and proprietary DNA-encoded platform. As described in a recent publication authored by X-Chem scientists ((Litovchick A, Clark MA, Keefe AD. Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags. Artificial DNA: PNA & XNA 2014; vol.5, number 1)) a key advancement is a library synthesis process that enables the addition of a DNA tag using chemical methods.
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