Rutgers Cancer Institute of New Jersey, a leader in cutting-edge clinical trials and a National Cancer Institute- designated Comprehensive Cancer Center, together with RWJBarnabas Health, today announced the publication of research that has identified and validated the novel Burkitt Lymphoma International Prognostic Index (
| NEW BRUNSWICK, N.J., Jan. 28, 2021 /PRNewswire/ -- Rutgers Cancer Institute of New Jersey, a leader in cutting-edge clinical trials and a National Cancer Institute- designated Comprehensive Cancer Center, together with RWJBarnabas Health, today announced the publication of research that has identified and validated the novel Burkitt Lymphoma International Prognostic Index (BL-IPI) in patients with this rare, high-grade B-cell lymphoma that is often studied in trials with small sample sizes. The research from the Burkitt Lymphoma International Prognostic Index Consortium is published in the January 2021 online issue of Journal of Clinical Oncology. (DOI: 10.1200/JCO.20.03288)
“Burkitt lymphoma has a unique biology and clinical course, and this type of cancer has historically lacked a standardized prognostic model,” said Andrew M. Evens, DO, MSc, FACP, Associate Director for Clinical Services and Director of the Lymphoma Program at Rutgers Cancer Institute and Medical Director of the Oncology Service Line at RWJBarnabas Health. “As part of an international collaborative, we developed and validated a simple yet robust prognostic model that accounts for the unique characteristics of Burkitt lymphoma to aid in risk stratification, interpretation of clinical trials and targeted development of innovative treatment approaches,” added Dr. Evens, who is senior and corresponding author of the work. Derived from 30 United States cancer centers and validated via multiple cancer centers in Europe, Canada and Australia, the BL-IPI is a simplified stratification of baseline clinical factors and comparison of risk distribution in geographically diverse cohorts. “This novel, validated index can help clinicians more accurately identify a prognosis for their adult Burkitt lymphoma patients, as well as advance targeted clinical research studies,” said Adam J. Olszewski, MD of the Lifespan Cancer Institute, associate professor of medicine at The Warren Alpert Medical School of Brown University in Providence, RI, and lead author of the study. “It may engender dual goals of de-escalating treatment intensity for patients with low-risk disease and improving survival rates for the high-risk group, the latter which has suboptimal outcomes with standard therapy and should be considered for novel therapeutic strategies.” “In addition, the availability of BL-IPI may also foster inquiry into molecular differences that lead to divergent clinical outcomes, which are not well explained by the gross indicators of disease burden at diagnosis,” adds Evens, who is also a Professor of Medicine at Rutgers Robert Wood Johnson Medical School. About Burkitt Lymphoma About the Research In the cohort of 633 patients with BL derived from the U.S. dataset, also known as the derivation cohort, the following were selected as equally weighted risk factors with independent prognostic value: 1) age greater than or equal to 40; 2) performance status greater than or equal to two; 3) serum lactate dehydrogenase greater than 3 times the upper limit of normal; and 4) central nervous system involvement. The resulting BL-IPI identified patient groups with low risk (0 risk factors, 18 percent of patients), intermediate risk (one factor, 36 percent of patients) and high risk (two or more factors, 46 percent of patients). The three groups had corresponding progression free survival (PFS) estimates of 92 percent, 76 percent and 59 percent, respectively, and 3-year overall survival estimates of 96 percent, 76 percent and 59 percent, respectively. The index differentiated these outcomes regardless of the patients’ HIV status, stage of disease or first-line chemotherapy regimen. In the external cohort of 457 BL patients treated in Europe, Canada and Australia used to validate the index, the patient characteristics, relative size of the BL-IPI groupings and outcome differentiation were consistent: 3-year PFS estimates of 96 percent, 82 percent and 63 percent for low-, intermediate- and high-risk BL, respectively. Limitations of the study include its retrospective design and a lack of formal central pathology review, although each case was diagnosed by expert academic hematopathologists and strict World Health Organization (WHO) criteria were applied. Additionally, a prognostic index will not necessarily predict patient benefit from any therapy, and the patient group risk estimates derived from the BL-IPI assume that all patients were treated with standard therapeutic approaches. This may not apply to patients older than 65 whose outcomes principally depend on whether they have comorbidities impacting their tolerance for intensive treatment. Further information on study limitations and additional findings can be found here: https://ascopubs.org/doi/full/10.1200/JCO.20.03288 This work was presented in part as an oral presentation at the 62nd ASH Annual Meeting and Exposition, December 5-8, 2020. About Rutgers Cancer Institute of New Jersey For journalists – contact: For patient appointments/inquiries – contact:
SOURCE Rutgers Cancer Institute of New Jersey and RWJBarnabas Health |
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