A new class of cholesterol lowering drugs, known as PCSK-9 antibodies, is generating a lot of excitement in cardiovascular medicine. PCSK-9 is a protein that destroys LDL receptors which are important for the removal of LDL cholesterol from the bloodstream. About a decade ago, it was observed that people born with a genetic defect that prevents them from producing PCSK-9 have very low LDL cholesterol and very little evidence of atherosclerosis. Based on this knowledge,, a race began in the biopharmaceutical industry to discover drugs that block the actions of PCSK-9.
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