MONTREAL, QUEBEC -- (MARKET WIRE) -- April 24, 2007 -- Ambrilia Biopharma Inc. (TSX: AMB), announced today that the findings of a Phase I/II clinical study conducted at the Memorial Sloan Kettering Cancer Centre (MSKCC) in New York City, indicate that the drug PCK3145 has shown evidence of clinical activity in metastatic prostate cancer patients. The therapeutic peptide drug PCK3145 was shown to increase PSA (Prostate Specific Antigen) doubling time (PSADT), suggesting clinical activity in such patients. The study also confirms down-regulation of MMP-9 (a matrix metalloproteinase enzyme involved in facilitating tumor metastasis), and disease stabilization as assessed by time to radiographic progression in several patients. The study of 28 metastatic hormone refractory patients was led by co-investigators Drs. Susan Slovin and Howard Scher.
