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People with advanced heart failure often live out the rest of their lives hoping that a donor heart might become available, and even if one does it’s often difficult for the recipient’s body to accept the new organ. Growing new hearts from stem cells may open the possibility of producing personalized organs that have an ideal size and shape, but more importantly that will not be rejected when transplanted. Researchers at the University of Pittsburgh School of Medicine have taken a major step toward that goal by successfully populating a decellularized mouse heart with human multipotential cardiovascular progenitor (MCP) cells and actually making it beat.
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