PENZBERG, Germany--(BUSINESS WIRE)--Cardiotoxicity, which results when drugs adversely affect the heart, explains why roughly one third of new pharmaceuticals are withdrawn from the market and why many compounds fail in late-stage clinical testing. To address this, a research team led by Kyle Kolaja, PhD, in the Department of Early and Investigative Safety, Nonclinical Safety, at Roche (SIX: RO, ROG; OTCQX: RHHBY), in Nutley, New Jersey, USA, reported in the June issue of Toxicological Sciences the identification of a model that more accurately detects drug-induced cardiac abnormalities. The novelty of this work is that it integrates two emerging technologies, stem cell derived tissues and impedance-based real-time cell monitoring.
