PENZBERG, Germany--(BUSINESS WIRE)--RNA interference studies are a powerful technology for high-throughput screening. However, endpoint analyses only provide a snapshot of the analyzed cellular phenotype, as it is not possible to measure developmental changes over time. To address this, a research team led by Stefan Wiemann and Ulrich Tschulena in the Division Molecular Genome Analysis of the German Cancer Research Center (DKFZ) in Heidelberg, Germany used the xCELLigence MP Instrument, from Roche (SIX: RO, ROG; OTCQX: RHHBY), to quantify cell proliferation, without the need for tagging or modifying sampled cells. As reported in the July 2011 (Zhang et al., Vol. 6, Issue 7) of PLoS ONE Online, they showed that the measurement of impedance strength is positively correlated with the number of cells attached to electrodes. Importantly, impedance measurements reflect not only cell number and also the quality of the cells’ interaction with their substrate, making this technology a sensitive and reliable way to assess cell status, including cell morphology, cell adhesion and cell viability.
