London, UK; Brentwood, TN, US; 14 August 2008 -- In accordance with Rule 2.10 of the City Code on Takeovers and Mergers (the "Code"), Protherics confirms that at the close of business on 13 August 2008, it has 342,159,034 ordinary shares of 2 pence each in issue and admitted to trading on the London Stock Exchange under the UK ISIN code GB0007029209.
