CHESHIRE, UK--(Marketwire - July 04, 2008) - Protherics PLC: Notification of Major Interests in Shares London, UK; Brentwood, TN, US: 4 July 2008 - Protherics PLC (“Protherics” or the “Company”), the international biopharmaceutical company focused on critical care and cancer, announces that on 3 July 2008, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies (“AXA”).