MELVILLE, N.Y.--(BUSINESS WIRE)--Dec. 5, 2005--OSI Pharmaceuticals, Inc. (NASDAQ: OSIP) announced today that in accordance with NASDAQ Marketplace Rule 4350(i)(1)(a)(iv), OSI granted stock options covering an aggregate of 640,210 shares to 165 new employees on December 1, 2005 as an inducement to entering into employment with the Company or a subsidiary of the Company.