MELVILLE, N.Y.--(BUSINESS WIRE)--OSI Pharmaceuticals, Inc., (Nasdaq: OSIP) today announced that it has initiated Phase I clinical trials for OSI-906, an orally active, potent and selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) inhibitor. The studies are designed to determine a recommended dose and dosing schedule for a Phase II trial, and will evaluate the safety and pharmacokinetic profiles of OSI-906. IGF-1R has been viewed as an important therapeutic target due to its involvement in the growth and proliferation of a variety of human cancers, including colorectal, prostate, non-small cell lung, breast and ovarian cancers. In addition, OSI-906 has been found to be active in colorectal human tumor xenografts and synergistic with Tarceva® (erlotinib) in non-small cell lung and pancreatic human tumor xenografts.
