SAN DIEGO, Aug. 25 /PRNewswire/ -- NexBio, Inc. announced today the publication “DAS181 Inhibits H5N1 Influenza Lung Virus Infection of Human Lung Tissues” in the September, 2009 issue of the journal Antimicrobial Agents and Chemotherapy (AAC).
The human lung tissue and cells described have been critical models for understanding the clinical pathogenesis of influenza, as people contain two types of receptors for influenza. While H5N1 preferentially binds to A2-3-linked Sia, Novel H1N1 preferentially binds to A2-6-linked Sia. DAS181 was shown in these studies to remove both the A2-6-linked and A2-3-linked types found in human respiratory tissue. Most importantly, virus was suppressed by inactivation of the entry receptors by DAS181 treatment.
In the “Report To The President On U.S. Preparations For 2009-H1N1 Influenza” by the President’s Council of Advisors on Science and Technology (PCAST) announced yesterday, it is recommended that “It will be important to develop new classes of drugs to expand the armamentarium. A particularly promising new approach is to develop drugs that block the virus by acting on a human cellular function (‘host target’), rather than a viral protein (‘pathogen target’), because such drugs should be less likely to encounter acquired resistance.” DAS181 development takes this “promising new approach.”
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* FDA has yet to approve the name Fludase.
NexBio, Inc.
