A newly identified set of genes may play a role in restless legs syndrome. Researchers have found two new genetic regions associated with an increased risk of restless legs syndrome (RLS). People with specific genetic variations in these regions or other previously identified genes linked to RLS are more likely to develop the disorder. Restless legs syndrome is one of the most common neurological disorders, affecting up to 10% of people over age 65. The condition causes tingling, prickling, and numbness in the legs with an urge to move them that occurs mainly when the body is at rest, usually at night.
