Patients with systemic autoimmune diseases such as lupus and rheumatoid arthritis (RA) often suffer loss of kidney function. When marked by a crescent formation in the glomerulus – a tiny ball comprised of capillary blood vessels integral to forming urine – kidney failure tends to be rapidly progressive, irreversible, and fatal. Little is known about the mechanism behind this crescent or its relationship to immune-mediated inflammation.>>> Discuss This Story