Nanobiotix Receives U.S. $1 Million Milestone Payment From PharmaEngine, Inc.

First patient injected with NBTXR3 in soft tissue sarcoma registration phase in Asia

Paris, France, Cambridge, MA, USA May 31, 2016 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer, receives a US$1m milestone payment from its Taiwan-based partner PharmaEngine.

The US$1m payment from PharmaEngine has been triggered by the injection of the first patient undergoing treatment in Nanobiotix’ Soft Tissue Sarcoma (STS) pivotal phase at a hospital in the Philippines.

About PharmaEngine and NBTXR3 development

PharmaEngine has a licensing agreement with Nanobiotix for the development and commercialization of Nanobiotix’s lead product, NBTXR3, in Asia-Pacific. As part of this agreement, Nanobiotix has already received upfront payments and milestone payments.

The Company is eligible to receive further development and commercialization milestone payments. Collectively, these payments may amount to a total of US$56 million plus tiered, up to double-digit royalties on all net product sales in the Asian-Pacific region.

Beyond the Act.in.sarc study, PharmaEngine is also running a pilot phase (phase I/II) in rectal cancer, and is expected to expand its development to include new indications.

About NANOBIOTIX: www.nanobiotix.com

Nanobiotix (Euronext: NANO / ISIN: FR0011341205) is a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer. The Company’s first-in-class, proprietary technology, NanoXray, enhances radiotherapy energy with a view to provide a new, more efficient treatment for cancer patients.

NanoXray products are compatible with current radiotherapy treatments and are meant to treat potentially a wide variety of solid tumors including soft tissue sarcoma, head and neck cancers, liver cancers, prostate cancer, breast cancer, glioblastoma, etc., via multiple routes of administration.

Nanobiotix’s lead product NBTXR3, based on NanoXray, is currently under clinical development for soft tissue sarcoma, head and neck Cancer, prostate cancer, rectal cancer (PharmaEngine) and liver cancers (HCC and liver metastases). The Company has partnered with PharmaEngine for clinical development and commercialization of NBTXR3 in Asia.

Nanobiotix is listed on the regulated market of Euronext in Paris (ISIN: FR0011341205, Euronext ticker: NANO, Bloomberg: NANO: FP). The Company Headquarter is based in Paris, France. Affiliate in Cambridge, United States.

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