Glasgow, Scotland, 14th June 2016 – MGB Biopharma, a biopharmaceutical company developing a truly novel class of anti-infectives to address the major global problem of antibiotic resistance, announces today that Dr Miroslav Ravic, CEO of MGB Biopharma, will present at the upcoming ASM Microbe 2016 meeting in Boston on [20 June 2016].
• Poster title: A Single-Centre, Double-Blind, Placebo-Controlled Study in Healthy Men to Assess the Safety and Tolerability of Single and Repeated Ascending Doses of MGB-BP-3, a New Class of Antibacterial Agent
• Date: Monday 20 June 2016
• Time: 12:30 PM - 2:30 PM
Dr Ravic will show that MGB Biopharma’s lead compound MGB-BP-3, which is orally-administered, was well tolerated in healthy volunteers at all dose levels tested in a Phase I clinical trial, with no dose limiting toxicity or serious adverse events noted. These results refer to the recently successful completion of a Phase I clinical trial of an oral formulation of MGB-BP-3 for the treatment of Clostridium difficile associated disease (CDAD).
MGB-based anti-infectives have the potential to deliver significant advantages over current approaches based on broad, bactericidal activity against many multi-drug resistant and susceptible Gram-positive pathogens. Other compounds from the platform have shown the potential to treat infection caused by Gram-negative, viral, fungal and parasitic organisms.
Dr Miroslav Ravic, CEO of MGB Biopharma, said: “At MGB Biopharma we believe our truly novel minor groove binder technology platform, could for the first time in many years, provide novel agents that offer a real breakthrough in combatting this major global public health concern. Our lead candidate, MGB-BP-3, has shown significant antibacterial activity against a range of important Gram-positive pathogens.”
Dr Ravic added: “We are now in the planning stage for a Phase II clinical trial to investigate the safety and efficacy of MGB-BP-3 in patients with CDAD, following our positive pre-IND meeting with the FDA.” While pursuing its clinical development activities, MGB Biopharma is now evaluating partnering and funding sources for its lead compound MGB-BP-3, which has the potential to offer a clear differentiated treatment option for patients with life threatening infections caused by resistant and susceptible Clostridium difficile strains.
