OHSU, Washington University researchers have identified the mechanism that makes a bioengineered enzyme function efficiently, opening the way to clinical development of the first safe clot busting agent for treating heart attacks and strokesA team of researchers at Oregon Health & Science University and Washington University in St. Louis have described for the first time the mechanism that gives a mutant enzyme molecule that they have engineered - and patented - the potential to become a breakthrough drug for treating heart attacks and strokes.