ImClone Systems Presenting At Banc of America Securities Securities 2004 Health Care Conference On May 19, 2004

HOUSTON, May 17 /PRNewswire-FirstCall/ -- Cyberonics, Inc. today announced that Robert P. (“Skip”) Cummins, Cyberonics’ Chairman and Chief Executive Officer, will be presenting at the Banc of America Securities Health Care Conference on May 19, 2004 at 4:40 PM local time at The Four Seasons Hotel in Las Vegas, Nevada.

Presentation slides will be available on line at http://www.cyberonics.com/ beginning Wednesday, May 19, 2004 at 7:30 PM EDT. Banc of America will host the webcast of the presentation live and by replay at http://www.veracast.com/webcasts/bas/healthcare-2004/id73113476.aspx . The replay of the presentation will begin 3 hours after the presentation time and will be available through June 4, 2004.

FORWARD LOOKING STATEMENTS

The Banc of America presentation contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. These statements can be identified by the use of forward-looking terminology, including “may,” “believe,” “will,” “expect,” “anticipate,” “estimate,” “plan,” “intend,” and “forecast,” or other similar words. Such forward- looking statements include statements concerning the timing and process of U.S. regulatory approval of VNS Therapy for depression, the timing and ultimate outcome of a final FDA decision regarding approvability and projections of future expenses, revenues, earnings and growth rates. Statements contained in the presentation are based upon information presently available to us and assumptions that we believe to be reasonable. We are not assuming any duty to update this information should those facts change or should we no longer believe the assumptions to be reasonable. Our actual results may differ materially. Important factors that may cause actual results to differ include, but are not limited to: continued market acceptance of VNS Therapy and sales of our product; the development and satisfactory completion of clinical trials and/or market test of VNS Therapy for the treatment of depression, Alzheimer’s disease, anxiety, or other indications; adverse changes in coverage or reimbursement amounts by third-parties; intellectual property protection and potential infringement claims; maintaining compliance with government regulations and obtaining necessary government approvals for new applications; product liability claims and potential litigation; reliance on single suppliers and manufacturers for certain components; our ability to hire, train and retain personnel; the accuracy of management’s estimates of future events, sales, expenses and earnings; and other risks detailed in from time to time in the Company’s filings with the SEC.

Cyberonics, Inc.

CONTACT: Pamela Westbrook, Vice President of Finance and CFO ofCyberonics, Inc., +1-281-228-7200, or fax, +1-281-218-9332, orpbw@cyberonics.com ; or Helen Shik, Vice President of Schwartz Communications,+1-781-684-0770 ext. 6587, or fax, +1-781-684-6500, or hshik@schwartz-pr.com ,for Cyberonics, Inc.

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