SAN DIEGO--(BUSINESS WIRE)--Hollis-Eden Pharmaceuticals, Inc. (NASDAQ:HEPH) is presenting new data this week showing that HE3286, an orally bio-available small molecule compound, produced a statistically significant reduction in disease in a rodent model of established arthritis. The data, being presented at the Keystone Symposium on Regulatory T Cells held February 1 - 6 in Vancouver, British Columbia, extend positive results from a previous preclinical study in which treatments of HE3286 initiated at disease onset significantly reduced disease. In that previous study, treated animals had nearly double the frequency of regulatory T cells in their spleens at the end of the 50-day study, suggesting that treatment with androstene hormones such as HE3286 can modulate the function and frequency of regulatory T cells in animals. Regulatory T cells have been shown to play major roles in the control of all immune responses. Specifically, deficiencies in regulatory T cell activity are thought to play a crucial role in the development of many autoimmune diseases, including arthritis and multiple sclerosis.
