EurekAlert! -- Massachusetts General Hospital (MGH) investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers. In their work published in the Jan. 18 Proceedings of the National Academy of Sciences, the team from the MGH Center for Engineering in Medicine (CEM) reports fabricating nanospheres containing keratinocyte growth factor (KGF), a protein known to play an important role in wound healing, fused with elastin-like peptides. When suspended in a fibrin gel, these nanoparticles improved the healing of deep skin wounds in diabetic mice.
