Mutations in proteins that turn genes on and off in the pancreas and liver may make you more likely to develop late-onset type 2 diabetes, researchers report.Late-onset type 2 diabetes is the result of poor regulation of blood sugar. Today in the United States there is an epidemic of type 2 diabetes, primarily due to obesity.Diabetes can lead to heart attacks, stroke and poor circulation, which can lead to amputation of the feet or legs. Diabetes can also lead to problems with vision that can cause blindness. Kidney and nerve problems are also common complications.