MALVERN, Pa. & MONTRÉAL--(BUSINESS WIRE)--Gemin X Pharmaceuticals, a clinical stage biopharmaceutical company developing novel, targeted cancer therapeutics, today announced the initiation of a Phase 2 clinical trial of its lead product candidate obatoclax (GX15-070) for the treatment of patients with extensive-stage small cell lung cancer (SCLC). In this multi-center, randomized, open-label Phase 2 study, clinical effect of a combination of carboplatin, etoposide and obatoclax (the “CEO” regimen) will be compared to the standard chemotherapeutic therapy of carboplatin and etoposide alone (the control arm) in patients with SCLC. The primary endpoint of the study, expected to enroll approximately 150 patients with SCLC, is comparison of overall response rate (ORR) for the obatoclax-containing arm versus the control arm. Secondary endpoints include comparison of progression free survival (PFS) and overall survival (OS), as well as safety.
