WALTHAM, Mass.--(BUSINESS WIRE)--Entasis Therapeutics, a leader in the discovery and development of breakthrough anti-infective products, today announced multiple presentations at the American Society of Microbiology (ASM) Microbe 2017 Conference, taking place June 1-5 in New Orleans, LA. Presentations will include data on Entasis’ lead program, ETX2514, as well as an introduction to Entasis’ third drug candidate, ETX0282.
The abstract titled “ETX1317, the Active Component of the Orally Available, Novel Diazabicyclooctenone ETX0282, Demonstrates Potential Utility against Multidrug Resistant Enterobactericeae Due to its Potent, Broad Spectrum Inhibition of Serine Beta-Lactamases,” has been designated as an oral presentation and will be presented on Friday, June 2 at 3:30 PM.
The details of the presentations are as follows:
ETX2514 Presentations:
Poster #82: The Antibacterial Activity of Sulbactam and the Novel
Beta-Lactamase Inhibitor ETX2514 Combined with Imipenem or Meropenem
against Recent Clinical Isolates of Acinetobacter baumannii and Pseudomonas
aeruginosa
Session: 036 - AAID01 - Antibacterial
Resistance: Beta-lactamase and Carbapenemase Inhibitors
Date and
Time: June 2, 2017 12:45 – 2:45 PM
Location: Exhibit
Hall D
Poster #277: Reversibility of ß-Lactamase Inhibition by the
Broad-Spectrum Diazabicyclooctenone Serine ß-Lactamase Inhibitor ETX2514
Session:
198 - AAID11 - New Antimicrobial Agents: New Beta-lactams and New
Beta-lactamase Inhibitors
Date and Time: June 3, 2017 12:15
– 2:15 PM
Location: Exhibit Hall D
ETX0282 Presentations:
Oral Presentation Title: ETX1317, the Active Component of the
Orally Available, Novel Diazabicyclooctenone ETX0282, Demonstrates
Potential Utility against Multidrug Resistant Enterobactericeae
Due to its Potent, Broad Spectrum Inhibition of Serine Beta-Lactamases
Session:
113 – Chemistry and Biological Attributes of Recent Beta-lactamase
Inhibitors, Three Different Approaches to Enzyme Inhibitions
Date
and Time: June 2, 2017 3:30 – 3:45 PM
Presentation Location: Room
225
Poster #278: ETX0282/Cefpodoxime Proxetil: A Novel, Oral
Beta-Lactam/Beta-Lactamase Inhibitor Combination to Treat the Emerging
Threat of Multidrug Resistant Enterobacteriaceae
Session:
198 - AAID11 - New Antimicrobial Agents: New Beta-lactams and New
Beta-lactamase Inhibitors
Date and Time: June 3, 2017 12:15
– 2:15 PM
Location: Exhibit Hall D
Poster #279: The Antibacterial Activity of Cefpodoxime and the
Novel Beta-Lactamase Inhibitor ETX1317 against Recent Clinical Isolates
of Beta-Lactamase-Producing Enterobacteriaceae from Urinary Tract
Infections
Session: 198 - AAID11 - New Antimicrobial Agents:
New Beta-lactams and New Beta-lactamase Inhibitors
Date and Time:
June 3, 2017 12:15 – 2:15 PM
Location: Exhibit Hall D
About ETX2514
ETX2514 is a potent and broad spectrum
inhibitor of class A, C, and D beta-lactamases. ETX2514 restores the in
vitro activity of multiple beta-lactams against Gram-negative,
multi-drug resistant (MDR) pathogens. Entasis Therapeutics is developing
ETX2514SUL, the combination of ETX2514 and sulbactam, for the treatment
of severe A. baumannii infections. A. baumannii is a
Gram-negative bacterium that causes severe infections which are
associated with high mortality rates. A. baumannii infections are
frequently multi-drug resistant and there is an urgent need to identify
new safe and effective agents to treat affected patients. Sulbactam is a
generic beta-lactam which has intrinsic activity against A. baumannii
but suffers from widespread beta-lactamase-mediated resistance. In
preclinical studies, ETX2514 restores sulbactam’s antimicrobial activity
against A. baumannii. ETX2514 is currently in Phase 1
clinical trials.
About ETX0282
ETX0282 is an orally available, broad spectrum
inhibitor of class A and C beta-lactamases. Entasis is developing
ETX0282 in combination with cefpodoxime, an orally available
cephalosporin approved for treating a variety of bacterial infections
but lacking in efficacy due to beta-lactamase mediated resistance. In
preclinical studies, ETX0282 restores cefpodoxime’s antimicrobial
activity against a variety of pathogens including
Enterobacteriaceae resistant to fluoroquinolones, cephalosporins,
and carbapenems. Entasis is initially developing ETX0282CPDP, the
combination of ETX0282 and cefpodoxime, for the treatment of infections
caused by Enterobacteriaceae. ETX0282CPDP is powered by CARB-X.
About Entasis Therapeutics Inc.
Entasis Therapeutics is
developing a portfolio of innovative cures for serious drug-resistant
bacterial infections, a global health crisis affecting the lives of
millions of patients. Entasis’ anti-infective discovery platform has
produced a pipeline of meaningfully differentiated programs which target
serious bacterial infections, including ETX2514SUL (targeting Acinetobacter
baumannii infections), ETX0282CPDP (targeting Enterobacteriaceae
infections), and zoliflodacin (targeting Neisseria gonorrhoeae). www.entasistx.com
Company Contact
Entasis Therapeutics
Kyle Dow,
781-810-0114
kyle.dow@entasistx.com
or
Media
Contact
MacDougall Biomedical Communications
Kari Watson,
781-235-3060
kwatson@macbiocom.com