Eilean Therapeutics LLC today announced the completion of a single ascending dose Phase 1 clinical study of lomonitinib and initiation of a multiple ascending dose Phase 1 program.
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[29-January-2024] |
DOVER, Del., Jan. 29, 2024 /PRNewswire/ -- Eilean Therapeutics LLC, a biopharmaceutical company dedicated to discovering and developing best-in-class and first-in-class small molecule inhibitors to target escape mutations in hematologic and solid malignancies, today announced the completion of a single ascending dose Phase 1 clinical study of lomonitinib and initiation of a multiple ascending dose Phase 1 program. Lomonitinib is a highly potent and selective pan-FLT3/ IRAK4 inhibitor that targets clinically relevant FLT3 mutations (ITD, TKD) including the gatekeeper mutation as well as putative escape pathways. The initial phase 1 program demonstrated excellent safety of lomonitinib with no reportable adverse events at exposures that resulted in robust target engagement. "The completion of the single ascending dose study of lomonitinib represents an important milestone for Eilean Therapeutics, as we progress, on plan, with an accelerated development of lomonitinib," stated Iain Dukes, Chief Executive Officer of Eilean Therapeutics. "The outstanding safety profile at exposures expected to exert a therapeutic benefit should enable lomonitinib to safely target FLT3 mutated AML and provides opportunities for development in multiple therapeutic settings where IRAK4 plays a significant role." About Lomonitinib About Eilean Therapeutics Media Contact:
SOURCE Eilean Therapeutics |